Augsburg’s bid to beat the Bundesliga drop takes them to Bayern Munich on Saturday, while fellow strugglers Hoffenheim meet Hamburg.
Markus Weinzierl’s side, competing in only their second season in Germany’s top flight, have taken just six points from their last six games to slide into the relegation play-off spot.
Matches against Bavarian neighbours Bayern have brought little cheer for Augsburg, with all four previous meetings have ended in defeat, and another reverse could see them slip into the bottom two.
Bayern may have their eye on the after-party, however, as they will finally get to lift the league winners’ trophy following the match, capping a remarkable domestic campaign.
Hoffenheim are also battling for their lives and defeat for them coupled with victories for Augsburg and Fortuna Dusseldorf would see them playing in the Bundesliga 2 next season.
They have shown resilience in their last eight games, accumulating 12 points to keep their survival hopes alive, and a clash with Markus Gisdol’s Hamburg, who can still quality for the UEFA Europa League, will further test their resolve.
The poor form of Dusseldorf and Werder Bremen, who are winless in 10 and 11 matches respectively, has kept things tight at the foot of the table.
Dusseldorf welcome a Nuremberg side whose own safety is assured despite having suffered four defeats on the bounce with only one goal to show for their efforts.
Werder have not tasted victory since February and their task gets no easier as they welcome UEFA Champions League hopefuls Eintracht Frankfurt, who will have an eye on fourth-placed Schalke’s match at home to Stuttgart.
Wolfsburg have an unlikely double in their sights as they look to replicate the 3-2 victory they achieved over Dortumund back in December and extend their unbeaten run to nine matches.
Already relegated Greuther Furth finish their home campaign with a match against Freiburg, who occupy the final UEFA Europa League qualifying spot.
Bayer Leverkusen, assured of third spot following a six-match unbeaten run, take on mid-table Hannover at the BayArena.
Mainz are on home soil against Borussia Monchengladbach as the hosts try to secure their first three-point haul in seven matches.