Tigre overturned a two-goal first-leg deficit to advance to the Copa Sudamericana quarter-finals with a 4-2 aggregate win on Thursday.
The Argentine team, who were beaten 2-0 at Ecuadorian club Deportivo Quito four weeks ago, prevailed 4-0 in a heated second leg in Buenos Aires.
Mariano Echevarria opened the scoring in the 10th minute, but the home side were on the back foot after 67 minutes when Ramiro Leone was shown a straight red card.
But the advantage in personnel last just four minutes for Quito, who had Jefferson Hurtado and substitute Michael Castro dismissed less than five minutes apart for second bookable offences.
Angel Diaz levelled the tie with a penalty in the 78th minute before Alejandro Donatti put Tigre in front on aggregate eight minutes later.
Ruben Botta sealed the result with less than a minute remaining before stoppage time, earning Tigre a last-eight showdown with Paraguayan outfit Cerro Porteno.
Elsewhere, Universidad Chile accounted for Ecuadorian side Emelec 3-2 on aggregate following a 1-0 win away from home in the second leg.
Universidad, who were held to a 2-2 draw in the first leg three weeks ago, scored the decisive goal through Enzo Gutierrez in the 58th minute.
The Chilean club face Sao Paulo next up, while Argentine team Independiente take on Universidad Catolica after beating Liverpool 4-2 on aggregate.
Independiente, who overcame the Uruguayan outfit 2-1 at home in the first leg, repeated the score in Montevideo.