PSV will look to extend their unbeaten start to the Eredivisie season against Go Ahead Eagles on Saturday, while Ajax host rivals Feyenoord.
PSV, the 2012-13 runners-up, have claimed all available points so far after winning 3-2 at ADO Den Haag and thrashing NEC 5-0 at the Philips Stadion on Saturday.
Teenage striker Zakaria Bakkali introduced himself to the PSV fans with three goals in the win over NEC, becoming the youngest ever Eredivisie player to net a hat-trick, while Georginio Wijnaldum scored the other two.
But Go Ahead Eagles will want to build on their last performance after picking up their first three points of the season with a narrow 2-1 victory over ADO, courtesy of a late goal from Marnix Kolder.
Ajax will hope to put Sunday’s 3-2 defeat to AZ Alkmaar behind them with a victory in their first derby of the season after the Dutch champions twice threw away the lead last time out.
And Frank de Boer’s side have a great opportunity to claim bragging rights after Feyenoord suffered their second successive defeat on Sunday to FC Twente.
The hosts took the lead through Graziano Pelle but went on to concede two penalties and have both Jordy van Deelen and Stefan de Vrij sent off during the 4-1 loss.
Twente will feel confident ahead of their home fixture this weekend as Utrecht visit De Grolsch Veste on the back of a 2-0 loss at Groningen, who are one of the four unbeaten teams this season.
The Euroborg outfit travel to Cambuur and NEC will host PEC Zwolle as both visiting sides look to preserve their 100 per cent records this season.
Heerenveen will hope Alfred Finnbogason can continue his early goalscoring form when Heracles visit on Sunday, after the striker notched his third goal during the 2-0 win at NAC Breda.
Elsewhere, Vitesse travel to Roda JC with new loan signing Lucas Piazon ready for his debut after the Brazilian followed Chelsea team-mates Patrick van Aanholt, Gael Kakuta and Cristian Cuevas to the GelreDome.
The visitors will want to get back to winning ways after a 4-2 defeat at RKC Waalwijk, who host AZ, in which Sander Duits netted two goals.
The other fixture this weekend will see NAC take on ADO at Rat Verlegh Stadion.