Twente defeated PSV Eindhoven 2-0 to take the lead in the Eredivisie, while bottom side Willem II lost 5-4 at home to Roda.
Theo Janssen opened the scoring from the penalty spot for hosts Twente in the 64th minute at De Grolsch Veste.
And the midfielder claimed a brace and wrapped up the win with his second goal six minutes from time.
The victory sees Twente replace PSV at the top of the table.
The defending champions are now two points clear with five matches left until the playoffs.
Elsewhere, Willem II led Roda 1-0 at half-time through a penalty from Andreas Lasnik.
Norwegian Pa-Modou Kah equalised for the visitors before Bart Biemans restored the hosts’ advantage.
Goals from Morten Skoubo, Ruud Vormer and Davy De Fauw then gave Roda a 4-2 lead.
Lasnik made it 4-3 with his second, before Vormer netted to restore Roda’s two goal cushion, and give the visitors a 5-3 lead with seven minutes to go.
There was still time for Willem II to go down to 10 men with the sending off of Arjan Swinkels.
Maceo Rigters struck the ninth goal of the game three minutes into injury time to make it 5-4, but Roda hung on for a topsy-turvy victory.
NAC Breda won 3-1 away to De Graafschap, who finished with nine men after Rogier Meijer and Leon Broekhof both saw red in the last 10 minutes.
Heerenveen led 2-0 by half-time in their match at home to Excelsior, but Geert Arend Roorda equalised with a five-minute double, before Nayib Lagouireh snatched all three points for the visitors with a goal two minutes into added time.
In the late kick-off, Charlison Benshop’s 44th minute effort helped AZ Alkmaar beat Feyenoord 1-0 away from home.
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