MK Dons thumped Cambridge City 6-1 in their FA Cup first-round replay on Tuesday, while Bradford City also advanced.
Non-league outfit Cambridge earned an historic replay after playing out a goalless draw over a week ago.
But they were no match for their League One opponents with a Shaun Williams brace and goals from James O’Shea, Dean Bowditch, Bamidele Alli and Adam Chicksen completing the crushing defeat at Stadium MK.
MK now face AFC Wimbledon in the second round and for the first time in their history.
It will mark a landmark day for the two clubs after AFC were founded in wake of the original Wimbledon’s move to Milton Keynes in 2002.
Bradford survived a scare at home to Northampton Town but did enough to progress from their first-round replay on penalties.
An under-strength Northampton side, who clinched a 1-1 draw almost a fortnight ago, forced the game into extra-time after Clive Platt scored in the dying moments of regulation time to make it 2-2.
The scores were level at 3-3 at the end of extra-time but Bradford held their nerve in the shootout, winning 4-2.
Elsewhere on Tuesday, Luton Town earned a second-round meeting with Dorchester after Scott Rendell scored a double to hand the conference side a 2-0 win over Nuneaton Town.
Morecombe will face Coventry City in the second round thanks to a 1-0 win over Rochdale and Mansfield overcame Slough Town 4-1 on penalties after full-time ended all-square at 1-1.
Next up for Mansfield is a trip to Lincoln, who prevailed 3-2 over Walsall in extra-time and an injury-time penalty from Garry Hunter handed Barrow a 1-0 win against Guiseley.
Meanwhile, Tranmere Rovers did what was expected of them, as they accounted for non-league Braintree 3-0 in the first round.