League Cup holders Manchester United will face last season’s beaten finalists Tottenham in the quarter-finals next month.
Sir Alex Ferguson’s side defeated Spurs 4-1 on penalties after a goalless 120 minutes at Wembley in March and they will meet the north Londonders again after Saturday’s draw.
Chelsea take on Blackburn at Ewood Park as Blues boss Carlo Ancelotti eyes his first major trophy with the club.
Arsenal, whose young stars saw off Liverpool in midweek, will travel to Manchester City, while Portsmouth host Aston Villa at Fratton Park.
The matches will take place in the week beginning November 30.
Blackburn v Chelsea
Manchester United v Tottenham
Portsmouth v Aston Villa
Manchester City v Arsenal
Ties to be played week commencing November 30