The German midfielder has found it hard to get much needed playing time following heavy summer recruitment and he continues to be linked with a move away from the club.
AS Roma were the first side to express interest in the 22-year-old footballer, but talkSPORT claims Inter Milan are also keen.
The Nerazzurri are pondering a January bid for Holtby, but they could face a stiff competition from other interested sides.
Lewis Holtby arrived at White Hart Lane in a high-profile move from Schalke in January 2013, but he has utterly failed to prove his worth in North London.
After making 11 Premier League appearances last term, he has featured in just one match this season, which is enough to suggest he is not exactly in first team plans of manager Andre Villas-Boas.