Last year’s MLS Eastern Conference winners Sporting Kansas City travel to leaders Houston Dynamo on Sunday, hoping to keep pace at the top.
Sporting were level on 17 points with Houston and New York Red Bulls before Wednesday’s surprise 1-0 defeat at home to Seattle Sounders and will be looking to claw back the three-point gap when they travel south.
Houston come into the clash off two straight away wins and hammered DC United 4-0 on Wednesday night to stay top with 20 points.
New York, sandwiched between Dynamo and Kansas City and only behind the former on goal difference, head north to face New England Revolution on Saturday.
Mike Petke’s Red Bulls have won their last four, with a spectacular Thierry Henry strike enough to see them edge past Montreal Impact 2-1 at the Red Bull Arena on Wednesday.
Western Conference leaders FC Dallas will look to strengthen their grip on top spot when they host DC United on Saturday.
Dallas are unbeaten in eight MLS matches but will be keen to return to winning ways after dropping points at home to Portland Timbers on Wednesday, drawing 1-1.
The Texas outfit, on 21 points, are four clear of Real Salt Lake, who travel to Canada to face Montreal Impact on Saturday while the Timbers, two points further back on 15, host Chivas USA on Sunday.
Elsewhere on Saturday, struggling Chicago Fire host Philadeplhia Union and the Sounders, second from bottom in the Western Conference, welcome San Jose Earthquakes to Seattle.
Vancouver Whitecaps, rock-bottom of the Western Conference face LA Galaxy at home and Columbus Crew, fifth in the Eastern Conference on 12 points face Colorado Rapids, sixth in the Western Conference.