Leicester City will be looking to tighten their grip at the top of the table when they take on Liverpool at the King Power Stadium on Tuesday evening.
The Foxes opened up a three point gap at the summit by beating Stoke City last time out and will move onto a half century of points with victory here, while they are currently only eight shy of the best total they have accumulated in a single Premier League season since the division’s inception.
Jurgen Klopp’s side edged past Norwich City last time out in the league and have booked their place in the final of the League Cup and drew 0-0 with West Ham United in the fourth round of the FA Cup since that win.
Victory here would move them to within ten points of their opponents and keep alive their hopes of making a push for a Champions League spot.
Second place Arsenal are one of three sides who could end the day in pole position, though they will need to beat Southampton if they are to have any chance of doing so.
Meanwhile the Saints recent run of three wins without conceding has seen them move up to eight place, just four points behind the top five.
Manchester City are also looking to reclaim top spot and have Sam Allardyce’s Sunderland standing in their way.
It is the first game for the title favourites since it was announced that Pep Guardiola will be replacing manager Manuel Pellegrini at the end of the season, and comes fresh on the back of the Citizens thrashing Aston Villa 4-0 in the FA Cup.
The Black Cats remain in the relegation zone, four points from safety and have the prospect of facing Liverpool and Manchester United once they have got this game out of the way.
Tottenham Hotspur are in fourth place and could move up to second if they beat struggling Norwich City, and other results fall in their favour while Manchester United host a Stoke City side who are just four places and four points below them going in to this round of fixtures.
West Ham United host basement club Aston Villa looking for a win that could see them leapfrog Louis van Gaal’s side into fifth place, with champions Chelsea taking their unbeaten run to Watford on Wednesday evening.
The Blues are slowly moving up the table but remain fourteen points off the top four with just fifteen games left to play.
Crystal Palace face a Bournemouth side looking to pull themselves further away from the bottom three while Everton welcome a Newcastle United boosted by three new signings on Wednesday.
Steve McClaren’s side remain in the drop zone but will have the opportunity to move above the dreaded dotted line should Norwich fail to win at Spurs.
Finally, West Bromwich Albion play Swansea City with both sides looking over their shoulders.
The Baggies are just seven points clear of danger, with the South Wales side just four above eighteenth place Newcastle.
Who will be on top of the Premier League come Wednesday morning?