Striker Wayne Rooney and goalkeeper David De Gea both trained with Manchester United on Monday ahead of the trip to Galatasaray.
Rooney missed the weekend defeat to Norwich with tonsillitis while De Gea was absent having had wisdom teeth removed.
Both were present at an open session ahead of their Champions League trip to Turkey.
However, midfielders Shinji Kagawa and Nani and defender Jonny Evans – who have been struggling with knee, hamstring and groin injuries respectively – were all absent for the first 15 minutes of the session which was open to the media.
Watching manager Sir Alex Ferguson is likely to give a number of players a rest as United have already won their group to ensure progress to the knock-out stage.
Although they are through midfielder Michael Carrick has no intention of spending the week trying to work out who they may play next.
“You can drive yourself mad thinking about who you might get and all the various permutations,” he said.
“We just have to win our games, which we have done, and see what the draw gives us.
“Whoever it is, we will be ready in February.”
The England international admitted that there was a better atmosphere around the club because of their success in Europe in 2012-13 compared to the difficulties they experienced in both the Champions League and the Europa League last season.
“It is a happier place because of what we are doing in the Champions League,” he said.
“Last year we were chasing our tails a bit and came up short. This year we have been ahead of the game.
“Getting those wins and points on the board makes it an awful lot easier.”
Phil Jones, meanwhile, is expected to make his first appearance of the season in central defence.
The 20-year-old has missed the start of the campaign with a knee injury.