Juventus will look to wrap up the Serie A title when they host relegation-threatened Palermo at the Juventus Stadium on Sunday.
Goals from Arturo Vidal and Claudio Marchisio in last Sunday’s derby victory over Torino maintained an 11-point gap over Napoli with just four fixtures remaining.
Palermo secured a crucial 1-0 victory over Inter in their previous league fixture to leave them one place above the relegation zone on goal difference.
They will hope that forward Fabrizio Miccoli can continue his lively partnership with Josip Ilicic from the Inter win as they look to claim a vital three points.
Inter will try to re-ignite their European qualification hopes as they travel to the Stadio San Paolo to face second-placed Napoli.
A 1-0 loss Palermo last Sunday left Inter in seventh place with four matches remaining. Javier Zanetti damaged his Achilles tendon in the match and adds to a growing injury list for the club that has severely hindered their progress.
Napoli will try to cement their grasp on the runners-up spot and secure a UEFA Champions League place.
A 3-0 victory at bottom-of-the-table Pescara last Sunday leaves them eight points clear of Fiorentina with 12 left to play for.
Fiorentina host Roma at the Stadio Artemio Franchi on Saturday in their bid to oust Milan in the battle for third. A Roma victory would keep their slim hopes of UEFA Champions League qualification alive but a loss would almost certainly end their chances.
Milan will be looking to capitalise on any dropped Fiorentina points to tighten their grasp on third place. They host Torino at the San Siro as the Turin outfit, who are not yet safe from relegation, will be looking to bounce back from their derby defeat to Juventus.
Udinese and Lazio both have home fixtures against Sampdoria and Bologna respectively on Sunday with both sides looking to claim a UEFA Europa League spot.
Elsewhere in Serie A Chievo play Cagliari on Saturday at the Stadio Marc’Antonio Bentegodi, while on Sunday Parma host Atlanta at the Stadio Ennio Tardini.
Also on Sunday, Pescara will be relegated if they don’t win their away fixture at Genoa and Siena’s battle for survival continues as they travel to Catania.