Champions Galatasaray ended their season with a 2-0 home win over Trabzonspor to finish 10 points clear of second-placed Fenerbahce.
Goals in each half from Albert Riera and Burak Yilmaz on Saturday wrapped up the points for the title winners, while Fenerbahce went down 3-2 away at Karabukspor, who secured their Super Lig survival.
Mehmet Topuz opened the scoring for the visitors before a Lomana Tresor Lua Lua penalty and an Ahmet Ozek strike put the strugglers in front.
Pierre Webo equalised for Fenerbahce but Lua Lua scored his second of the game to hand Karabukspor the points.
On Sunday, third-placed Besiktas also ended their campaign in defeat, as goals from Yener Arica and Bobo saw fifth-placed Kayserispor to a 2-0 home success.
Fourth-placed Bursaspor drew 2-2 away at Genclerbirligi. Ferhat Kiraz opened the scoring for the visitors before Ozgur Ileri and Ermin Zec put the hosts ahead, but the points were shared as Murat Yildirim found the net for Bursaspor with 15 minutes remaining.
Elsewhere in the final round of fixtures, Elazigspor and Sivasspor played out a goalless draw, while Eskisehirspor defeated Antalyaspor 3-1 thanks to a first-half brace from Ozgur Cek and a second-half strike from Diomansy Kamara.
The remaining three fixtures of the round all saw away wins.
A Bruno Mezenga brace saw Akhisar Belediyespor to a 2-0 success over Orduspor, and Kasimpasa came from behind to defeat Istanbul BB 2-1.
Tevfik Kose gave the hosts an early lead, but Djalma equalised for Kasimpasa, who snatched the points courtesy of an 89th-minute winner from Halil Colak.
On Friday, bottom club Mersin Idmanyurdu went down 2-1 at home to Gaziantepspor, who finished tenth.