Managerless Galatasaray will aim to bounce back from their 6-1 loss to Real Madrid in the UEFA Champions League when they visit Juventus.
Fatih Terim paid the price for a poor start to the season that has yielded just one win in five league matches, as well as the disappointing showing against Real in front of their home supporters.
The Super Lig champions were outclassed by the Spanish giants in the Group B opener, with Cristiano Ronaldo once more stealing the show with a second-half hat-trick in the comfortable rout.
Roberto Mancini is widely expected to take control at the Turk Telecom Arena, with the Turkish outfit confirming on Sunday that they were in talks with the Italian.
The 48-year-old has been out of work since parting company with Manchester City in May.
Galatasaray head into the fixture at the Juventus Stadium on Wednesday on the back of a 1-1 draw at home to Rizespor. Engin Baytor opened the scoring, but Tevfik Kose levelled in the second half before Slcuk Inan saw red.
Midfielder Hamit Altintop continues to be plagued by a hip injury and is likely to miss the visit to Turin.
Reigning Serie A champions Juventus will be desperate to claim a maximum haul after a disappointing 1-1 draw away to Copenhagen in their opening fixture.
Antonio Conte’s team are in good form ahead of Wednesday’s showdown, and are on an eight game unbeaten run in all competitions.
They will look to build on the momentum from their 1-0 victory over rivals Torino at the Stadio Olimpico on Sunday, with Paul Pogba’s second-half header securing the points.
The France international has now set his sights on the Champions League, and said the side are itching to atone for their surprise draw against Copenhagen.
Speaking to Tuttosport , he said: “We know it will be an important match for us, we have to win it and we know it won’t be easy.
“I don’t know if it will be decisive for qualification, but after the draw with Copenhagen we all want to win.”
Juventus could be without influential striker Carlos Tevez after he picked up an ankle injury against Torino following a robust challenge from Ciro Immobile.
The Argentinian has notched three times in the league for the Turin outfit since his transfer-window move from Manchester City.