The latest reports are suggesting that Manchester United boss David Moyes could face a real selection headache ahead of the crunch tie with Bayer Leverkusen on Wednesday.
The Red Devils are one point clear at the top of Group A ahead of the trip to Bay Arena, but they go into the game in poor spirits having failed to defeat Cardiff City at the weekend.
And while David Moyes was hoping to rest star forward Wayne Rooney in midweek, he may not be able to do so given that both Robin van Persie and Danny Welbeck are rated doubtful at the moment.
With Nemanja Vidic, Rafael da Silva, Phil Jones and Shinji Kagawa also facing fitness tests, and Carrick and Fellaini definitely out, the Red Devils clearly face a tough task in Germany.
And with the Germans having won eight of nine home matches this season, they are rightly considered 7/5 favourites to claim maximum points.
Meanwhile, Manchester United are 11/5 to secure the victory that would seal qualification to the knockout stages, with Robin van Persie 2/1 to score anytime.
Bayer Leverkusen have worries of their own, with star forward Sidney Sam ruled out with a torn muscle, but they will have Stefan Reinartz back to the side.