Serie A winners Inter will begin their title defence with a home match against Genoa.
Fixtures for the 2021-22 season were announced on Wednesday, with the side now coached by Simone Inzaghi given a San Siro opener.
That means city rivals Milan, who were runners-up last year, will begin with an away contest against Sampdoria in the week ending August 22.
Juventus, meanwhile, will start their bid to regain the Scudetto under Massimiliano Allegri with an away fixture against Udinese.
The Old Lady host Empoli in week two before a crunch clash away to Napoli on matchday three.
A tricky start continues for Allegri as he will then face former club Milan, with Juve at home for that huge clash on matchday four.
(@Inter) July 14, 2021
Inzaghi will take on former club Lazio for the first time on week eight, a week before the first Derby d’Italia against Juve the following matchday, week ending October 24.
The first Milan derby has provisionally been scheduled for the weekend of November 7, which is week 12 of the campaign.
Inter play Milan for the second time on February 6 with their second contest against Juve coming towards the end of the season on April 3.
Should the title race go down to the last day of the season, Inter end their league campaign at home to Sampdoria, while Juve travel to Fiorentina and Milan face Sassuolo.
Serie A week one fixtures:
Bologna v Salernitana
Cagliari v Spezia
Empoli v Lazio
Verona v Sassuolo
Inter v Genoa
Napoli v Venezia
Roma v Fiorentina
Sampdoria v Milan
Torino v Atalanta
Udinese v Juventus
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