Manchester United play host to Sporting Braga, while CFR Cluj take on Galatasaray in Group H of the Champions League on Tuesday.
While Braga are undefeated in their past five matches against English opposition, United are hot favourites to continue their perfect start to the competition at Old Trafford.
United, who failed to reach the knockout phase last season, head into the contest on top of the group with wins against Galatasaray and Cluj.
Ashley Young is expected to return for United following a knee injury, while Tom Cleverley, Shinji Kagawa and Darren Fletcher could also feature after being rested in the Premier League at the weekend.
United recovered from a goal down to defeat Stoke City on Saturday and manager Sir Alex Ferguson has put the onus on his defenders to be more reliable in the early stages.
“We keep starting badly in games, in the first 20 minutes,” he told MUTV.
“There’s no doubt our attacking play has been the strongest part of our game. But we’re letting in goals at home and that’s disappointing.”
Braga, who rebounded from an opening loss to Cluj with a deserved win over Galatasaray, travel to Manchester unbeaten in their past five outings in all competitions.
In Istanbul, Galatasaray hope to keep their chances of progressing beyond the group stage alive with their first points of the tournament.
Fatih Terim’s men are rooted to the bottom of the group with two losses from their opening two games and could be all but eliminated with a third defeat.
Cluj head to Turkey on the back of two straight losses in the Romanian top flight but remain second in their European group with three points and a superior goal difference.