Luc Castaignos and Nacer Chadli led Twente the top of the Eredivisie after a 3-2 win over Heracles in driving rain in Enschede.
Despite going behind in the first half, Twente recovered in front of their home fans to take the lead just after the hour mark.
Heracles hit back soon after with an equaliser from Thomas Bruns but Castaignos sealed the three points in the Derby of the East when he scored from Chadli’s precise pass in the 70th minute.
Friday’s win means Twente move to 37 points, one ahead of PSV Eindhoven.
PSV can regain the lead if they win away to NEC Nijmegen, while if the Eindhoven club slip up, Vitesse Arnhem could go top with a victory at home against RKC Waalwijk.
Heracles remain 10th with 19 points from their 17 games.
In Enschede, visiting Heracles, who only had to travel 30 kilometres to take on their local rivals, opened the scoring in the 20th minute when Marko Vejinovic curled his free kick inside the near post.
As heavy rain fell at De Grolsch Veste, Twente equalised six minutes later after a mistake from Heracles goalkeeper Remko Pasveer.
The 29-year-old tried to clear a back pass down the middle of the pitch but did not get enough elevation on his kick and Twente captain Wout Brama pounced on the loose ball, passed straight to Chadli and the Belgian scored easily past an out-of-position Pasveer.
Twente moved ahead of Heracles in the 62nd minute when Castaignos set up Edwin Gyasi but the visitors were level two minutes later when Bruns slid in to tap Geoffrey Castillion’s cross past Boschker.
With the match up for grabs, Twente scored the decisive goal 20 minutes from full time when a counter-attack culminated in Chadli slipping a pin-point pass to Castaignos at the back post and the 20-year-old striker had enough time to take a touch and pick his spot to score.