Thursday, May 21, 2026

Prediction: Southampton vs Arsenal – Betting Tips, Team News, Key Facts

Tom Dunstan in FA Cup, Free Soccer Predictions 2 Apr 2026

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Verdict: Arsenal win & Both teams to score

Best Odds: 2/1

Bookmaker: Olympusbet

Looking to book their FA Cup semi-final spot on Saturday night, Arsenal will travel to St. Mary’s when they meet Southampton.

Southampton

Starting with the hosts, while Tonda Eckert might have only arrived at St. Mary’s back in December, Southampton have embarked on a sensational rise under the German tactician. With their sights firmly set on booking an immediate Premier League return in 2026, the Saints find the mood in their camp at a red-hot high. Last seen heading into March’s international break with a routine 2-0 victory at home against Oxford, Eckert’s side are riding a major wave of momentum. Including a stunning 2-1 win away at Championship leaders Coventry on March 14th, Southampton are unbeaten in all of their previous 14 consecutive appearances across all competitions (11 wins, three draws). With that purple patch stemming all the way back to January 17th, the Saints should be relishing the chance to steal centre stage on Saturday night.

Southampton Team News

Still sidelined with a long-term Achilles tendon injury, Southampton will once again be without former Brentford defender Mads Roerslev Rasmussen this weekend. Likewise, Brazilian defender Welington is still recovering from a muscle issue.

Featuring for Canada over the past fortnight, January recruit Cyle Larin should spearhead Southampton’s charge on Saturday night. Finding the net against Oxford prior to March’s international break, Norther Ireland international Shea Charles will be hoping to keep his spot in the middle of the park.

Arsenal

As for the visitors, suffering real EFL Cup heartbreak at Wembley prior to March’s international break as they slumped to a 2-0 loss against Manchester City, Arsenal watched their quadruple dreams go up in smoke. Nevertheless, still leading the chase at the top of the Premier League table and sat in the driving seat to get their hands on a first domestic crown since way back in 2004, Mikel Arteta’s camp are still on the cusp of making real history this season. Holding a commanding nine-point buffer over the chasing pack, Arsenal will travel to St. Mary’s on Saturday night looking to claim an immediate boost. Landing a 2-1 win when they last travelled to Southampton back in 11 months ago, Arteta’s side will be desperate to avoid what could be a potential FA Cup banana skin this weekend.

Arsenal Team News

While both Bukayo Saka and Declan Rice might have left England’s camp early last week, both are expected to be free to feature on Saturday night. However, with fitness concerns over the likes of Martin Zubimendi, Piero Hincapie and Jurrien Timber, Arteta is expected to make a string of alterations here.

Despite his EFL Cup nightmare at Wembley last time out, former Chelsea goalkeeper Kepa Arrizabalaga could keep his spot between the sticks. England international Myles Lewis-Skelly should make just a second start across any competition since the end of January.

Southampton vs Arsenal Key Factors to Consider

    • When Arsenal last travelled to St. Mary’s back in May 2025, the Gunners clinched a 2-1 victory.
    • Arsenal’s 2-0 EFL Cup final defeat against Manchester City last time out brought an end to their 14-match unbeaten run across all competitions.
    • Southampton are unbeaten in all of their previous 14 consecutive appearances across all competitions (11 wins, three draws).
    • Arsenal have registered just a single clean sheet from any of their last seven consecutive matchups away from the Emirates.
    • The Saints have suffered just a single defeat at St. Mary’s since back on November 1st.

    Conclusion

    Facing what could be a potential FA Cup banana skin this weekend, Arsenal will meet a Southampton squad who find themselves at the heart of a sensational run. With the Gunners seeking an immediate response following on from their Wembley nightmare last time out, Arteta’s camp will certainly be under the microscope here. Landing a 2-1 victory when they last travelled to St. Mary’s back in May 2025, we are expecting a similar outcome on the south coast.

    Verdict: Arsenal win & Both teams to score

    Best Odds: 2/1

    Bookmaker: Olympusbet

    ABOUT THE AUTHOR

    Tom Dunstan


    Formerly of The Independent, Tom has spent the past six years as one of our senior writers and betting experts. Alongside working with numerous publications from across the globe, Tom also graduated from the University of Falmouth in 2014 with a Bachelor of Arts Degree in Digital Media.
    Spending almost the past decade working in countries such as Australia, New Zealand and Canada, he has also spent time featuring in sports radio. Tom can be followed on Instagram - @iamtomdunstan

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